Discovering new causes of coronary artery disease enables detection, prevention, and treatment. We focus on understanding the causes of coronary artery disease by taking an approach that intersects human genetics with deep phenotyping through invasive and non-invasive coronary imaging and physiology. In addition to association analyses on genomic data from biobanks, we leverage catheterization-based imaging and physiology of the coronary circulation and coronary CT plaque imaging to better understand patterns and subtypes of atherosclerosis, as well as poorly studied non-atherosclerotic coronary artery diseases such as microvascular and endothelial dysfunction and spontaneous coronary artery dissection.