selected publications
Misra A, Jowell A,…, Fahed AC, Natarajan P*, Patel AP*. Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions J Am Coll Cardiol. 2026 Apr.
Misra A, Jowell A,…, Fahed AC, Natarajan P*, Patel AP*. Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions J Am Coll Cardiol. 2026 Apr.
Abou-Karam R, Allard-Ratick MP, …, Garasic JM, Fahed AC. Safe implementation of an expedited radial hemostatic compression device removal protocol in the cardiac catheterization lab. Cardiovasc Revasc Med. 2026 Apr.
Abou-Karam R, Allard-Ratick MP, …, Garasic JM, Fahed AC. Safe implementation of an expedited radial hemostatic compression device removal protocol in the cardiac catheterization lab. Cardiovasc Revasc Med. 2026 Apr.
Bitar F, Zareef R, …, Bitar FF, Fahed AC, Sater ZA. Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation. Front Med (Lausanne). 2026 Apr.
Bitar F, Zareef R, …, Bitar FF, Fahed AC, Sater ZA. Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation. Front Med (Lausanne). 2026 Apr.
Ratman D, Maier R, …, Rabinowitz M, Im K, Fahed AC. Stability of integrated polygenic and clinical coronary artery disease risk prediction. Am J Prev Cardiol. 2026 Feb.
Ratman D, Maier R, …, Rabinowitz M, Im K, Fahed AC. Stability of integrated polygenic and clinical coronary artery disease risk prediction. Am J Prev Cardiol. 2026 Feb.
Schonck WA, Hovingh GK, …, Roeters van Lennep JE, Fahed AC,… , Reeskamp LF; Homozygous Familial Hypercholesterolemia International Clinical Collaborators. Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry. Atherosclerosis. 2026 Apr.
Schonck WA, Hovingh GK, …, Roeters van Lennep JE, Fahed AC,… , Reeskamp LF; Homozygous Familial Hypercholesterolemia International Clinical Collaborators. Traditional cardiovascular risk factors and their association with atherosclerotic cardiovascular disease in homozygous familial hypercholesterolemia: A cross-sectional analysis from the HICC registry. Atherosclerosis. 2026 Apr.
Reynolds HR, Maehara A, …, Hashim HD, Bainey KR, Fahed AC, Pinilla Echeverri N, …, Hochman JS; HARP Research Group. Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. Circulation. 2026 Mar.
Reynolds HR, Maehara A, …, Hashim HD, Bainey KR, Fahed AC, Pinilla Echeverri N, …, Hochman JS; HARP Research Group. Multi-modality Imaging to Determine Underlying Causes of MINOCA in Women and Men. Circulation. 2026 Mar.
Yang X, Kim MS, …, Gabriel SB, Ellinor PT; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Natarajan P, Wang M, Fahed AC. An integrated germline and somatic genomic model for coronary artery disease. Nat Commun. 2026 Mar.
Yang X, Kim MS, …, Gabriel SB, Ellinor PT; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Natarajan P, Wang M, Fahed AC. An integrated germline and somatic genomic model for coronary artery disease. Nat Commun. 2026 Mar.
Bitar F, Abou-Karam R, …, Jaffer FA, Fahed AC. Diagnostic Yield and Testing Characteristics of an Invasive Coronary Function Testing Program. Catheter Cardiovasc Interv. 2026 Mar.
Bitar F, Abou-Karam R, …, Jaffer FA, Fahed AC. Diagnostic Yield and Testing Characteristics of an Invasive Coronary Function Testing Program. Catheter Cardiovasc Interv. 2026 Mar.
Bitar F, Zareef R, …, Bulbul Z, Bitar FF*, Fahed AC*. Economic modeling of polygenic risk prediction of coronary artery disease in childhood. NPJ Cardiovasc Health. 2026 Mar.
Bitar F, Zareef R, …, Bulbul Z, Bitar FF*, Fahed AC*. Economic modeling of polygenic risk prediction of coronary artery disease in childhood. NPJ Cardiovasc Health. 2026 Mar.
Farah R, Kim MS, …, Patel A, Ridker PM, Natarajan P, Fahed AC. Combining Genomics With Lipid and Inflammatory Biomarkers to Predict Coronary Artery Disease Risk: UK Biobank Study. J Am Coll Cardiol. 2026 Mar.
Farah R, Kim MS, …, Patel A, Ridker PM, Natarajan P, Fahed AC. Combining Genomics With Lipid and Inflammatory Biomarkers to Predict Coronary Artery Disease Risk: UK Biobank Study. J Am Coll Cardiol. 2026 Mar.
Kim MS, Chen Q, …, Liao S, Liu Z, Alkuraya FS, Natarajan P, Ellinor PT, Fahed AC, Wang M. Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities. Cell Metab. 2026 Mar.
Kim MS, Chen Q, …, Liao S, Liu Z, Alkuraya FS, Natarajan P, Ellinor PT, Fahed AC, Wang M. Metabolic polygenic risk scores for prediction of obesity, type 2 diabetes, and related morbidities. Cell Metab. 2026 Mar.
Cho SMJ, Ruan Y, …, Honigberg MC, Fahed AC, Patel AP, Hornsby WE, Natarajan P. Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension. Hypertension. 2026 Mar.
Cho SMJ, Ruan Y, …, Honigberg MC, Fahed AC, Patel AP, Hornsby WE, Natarajan P. Blood Pressure Polygenic Score Predicts Long-Term Blood Pressure Control and Treatment-Resistant Hypertension. Hypertension. 2026 Mar.
Abou-Karam R, Kim MS, …, Ghebremichael MS, Atlas SJ, Ridker PM*, Lu MT*, Fahed AC*. Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials. J Am Coll Cardiol. 2026 Feb.
Abou-Karam R, Kim MS, …, Ghebremichael MS, Atlas SJ, Ridker PM*, Lu MT*, Fahed AC*. Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials. J Am Coll Cardiol. 2026 Feb.
Kim MS, Shim I, …, Fahed AC*, Won HH*. Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks. Am J Prev Cardiol. 2026 Feb.
Kim MS, Shim I, …, Fahed AC*, Won HH*. Body mass index threshold for obesity should be personalized based on polygenic score: Analysis of european and east asian biobanks. Am J Prev Cardiol. 2026 Feb.
Chen X, Wang F, …, Yu K, Zaib K, Fahed AC, Zhai G, Wang M. Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform. Nat Commun. 2026 Jan.
Chen X, Wang F, …, Yu K, Zaib K, Fahed AC, Zhai G, Wang M. Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform. Nat Commun. 2026 Jan.
El Ghazawi A, Fahed AC, …, Fakih Y, Alam S, Refaat M. Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction. Am Heart J Plus. 2026 Jan.
El Ghazawi A, Fahed AC, …, Fakih Y, Alam S, Refaat M. Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction. Am Heart J Plus. 2026 Jan.
Bedrouni W, Bedrouni M, …, Fahed AC, Anand SS, …, Huynh T. Grant Funding for Immigrant Cardiovascular Health Research in the US and Canada. JAMA Netw Open. 2025 Dec.
Bedrouni W, Bedrouni M, …, Fahed AC, Anand SS, …, Huynh T. Grant Funding for Immigrant Cardiovascular Health Research in the US and Canada. JAMA Netw Open. 2025 Dec.
Koyama S, Wang Y, …, Sui Y, Fahed AC, Kamineni H, Haidermota S, …, Martin AR, Natarajan P. Genetics and context for precision health in Greater Boston. Nat Commun. 2025 Nov.
Koyama S, Wang Y, …, Sui Y, Fahed AC, Kamineni H, Haidermota S, …, Martin AR, Natarajan P. Genetics and context for precision health in Greater Boston. Nat Commun. 2025 Nov.
Supriami K, Faaborg-Andersen CC, …, Hornsby W, Natarajan P, Ellinor PT, Honigberg MC, Fahed AC. Outcomes after coronary angiography in individuals with elevated lipoprotein(a). Eur J Prev Cardiol. 2025 Nov.
Supriami K, Faaborg-Andersen CC, …, Hornsby W, Natarajan P, Ellinor PT, Honigberg MC, Fahed AC. Outcomes after coronary angiography in individuals with elevated lipoprotein(a). Eur J Prev Cardiol. 2025 Nov.
Galo J, Maksoud A, …, Kobayashi Y, Fahed AC, Shlofmitz E, Sharma A, …, Bergmark B, Hashim H. Predictors of Variability in Coronary Flow Reserve and Microvascular Resistance Measurement Using the Bolus Thermodilution Technique. Catheter Cardiovasc Interv. 2026 Jan.
Galo J, Maksoud A, …, Kobayashi Y, Fahed AC, Shlofmitz E, Sharma A, …, Bergmark B, Hashim H. Predictors of Variability in Coronary Flow Reserve and Microvascular Resistance Measurement Using the Bolus Thermodilution Technique. Catheter Cardiovasc Interv. 2026 Jan.
Mashlah A, Marini S, …, Salim A, Fahed AC, Manley GT, Halabi C, Digiorgio A, Zafonte R, Izzy S. Traumatic Spinal Cord Injury and Subsequent Risk of Developing Chronic Cardiovascular, Neurologic, Psychiatric, and Endocrine Disorders. JAMA Netw Open. 2025 Nov.
Mashlah A, Marini S, …, Salim A, Fahed AC, Manley GT, Halabi C, Digiorgio A, Zafonte R, Izzy S. Traumatic Spinal Cord Injury and Subsequent Risk of Developing Chronic Cardiovascular, Neurologic, Psychiatric, and Endocrine Disorders. JAMA Netw Open. 2025 Nov.
Urbut SM, Chen Q, …, Alkuraya F, Fahed AC, Wang M, Natarajan P. Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries. NEJM Evid. 2025 Nov.
Urbut SM, Chen Q, …, Alkuraya F, Fahed AC, Wang M, Natarajan P. Genetics of Cholesterol and Coronary Disease Risk across Six Global Ancestries. NEJM Evid. 2025 Nov.
Maamari DJ, Biddinger KJ, …, Huffman JE, Fahed AC, Sarma AA, …, Ellinor PT, Aragam KG. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA Cardiol. 2025 Nov.
Maamari DJ, Biddinger KJ, …, Huffman JE, Fahed AC, Sarma AA, …, Ellinor PT, Aragam KG. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA Cardiol. 2025 Nov.
Zhang R, Kim MS, …, Ellinor PT*, Wang M*, Fahed AC*. Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation. JAMA Cardiol. 2025 Oct.
Zhang R, Kim MS, …, Ellinor PT*, Wang M*, Fahed AC*. Contributions of Common, Rare, and Somatic Genetic Variants to Incidence of Atrial Fibrillation. JAMA Cardiol. 2025 Oct.
Bergmark BA, Shah S, …, Kobayashi Y, Fahed AC, Hashim H, …, Sabatine MS. Multicenter Prospective Assessment of Coronary Microvascular Dysfunction: Primary Results of the FlowLab Study. JACC Adv. 2025 Nov.
Bergmark BA, Shah S, …, Kobayashi Y, Fahed AC, Hashim H, …, Sabatine MS. Multicenter Prospective Assessment of Coronary Microvascular Dysfunction: Primary Results of the FlowLab Study. JACC Adv. 2025 Nov.
Kim MS, Park S, …, Sui Y, Fahed AC, Ellinor PT, …, Won HH. ACE inhibition increases Alzheimer’s disease risk by promoting tau phosphorylation. medRxiv. 2025 Aug.
Kim MS, Park S, …, Sui Y, Fahed AC, Ellinor PT, …, Won HH. ACE inhibition increases Alzheimer’s disease risk by promoting tau phosphorylation. medRxiv. 2025 Aug.
Kany S, Friedman SF,… Ellinor PT*, Fahed AC*. Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease. JACC Adv. 2025 Sep.
Kany S, Friedman SF,… Ellinor PT*, Fahed AC*. Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease. JACC Adv. 2025 Sep.
Cho SMJ, Levin M,…, Fahed AC,… Natarajan P*. AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations. J Am Coll Cardiol. 2025 Jul 22. PMID: 40669956
Cho SMJ, Levin M,…, Fahed AC,… Natarajan P*. AHA PREVENT Equations and Cardiovascular Disease Risk in Diverse Health Care Populations. J Am Coll Cardiol. 2025 Jul 22. PMID: 40669956
Kim MS, Song M,… Ellinor PT*, Fahed AC*, Won HH*. Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures. medRxiv [Preprint] 2025 Jul 2. PMID: 40630572
Kim MS, Song M,… Ellinor PT*, Fahed AC*, Won HH*. Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures. medRxiv [Preprint] 2025 Jul 2. PMID: 40630572
Kim MS, Khurshid S,… Ellinor PT*, Fahed AC*. Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models. Circ Genom Precis Med. 2025 Jun 17. PMID: 40525300
Kim MS, Khurshid S,… Ellinor PT*, Fahed AC*. Machine Learning-Based Plasma Protein Risk Score Improves Atrial Fibrillation Prediction Over Clinical and Genomic Models. Circ Genom Precis Med. 2025 Jun 17. PMID: 40525300
Khan N, Shaar A,… Fahed AC, Saad M. Genome-Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores. J Am Heart Assoc. 2025 Mar 4. PMID: 40008532
Khan N, Shaar A,… Fahed AC, Saad M. Genome-Wide Association Study for Resting Electrocardiogram in the Qatari Population Identifies 6 Novel Genes and Validates Novel Polygenic Risk Scores. J Am Heart Assoc. 2025 Mar 4. PMID: 40008532
Misra A, Truong B,… Fahed AC, Smoller JW, Patel AP, Natarajan P. Instability of high polygenic risk classification and mitigation by integrative scoring. Nat Commun. 2025 Feb 12. PMID: 39939586
Misra A, Truong B,… Fahed AC, Smoller JW, Patel AP, Natarajan P. Instability of high polygenic risk classification and mitigation by integrative scoring. Nat Commun. 2025 Feb 12. PMID: 39939586
Urbut SM, Cho SMJ,…, Fahed AC*, Natarajan P*. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. Circ Genom Precis Med. 2025 Jan 24. PMID: 39851049
Urbut SM, Cho SMJ,…, Fahed AC*, Natarajan P*. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. Circ Genom Precis Med. 2025 Jan 24. PMID: 39851049
Maamari DJ, Abou-Karam R, Fahed AC. Polygenic Risk Scores in Human Disease. Clin Chem. 2025 Jan 3. PMID: 39749511.
Maamari DJ, Abou-Karam R, Fahed AC. Polygenic Risk Scores in Human Disease. Clin Chem. 2025 Jan 3. PMID: 39749511.
Supriami K, Urbut SM, …, Natarajan P, Ellinor PT, Fahed AC. Genomic Drivers of Coronary Artery Disease and Risk of Future Outcomes After Coronary Angiography. JAMA Netw Open. 2025 Jan 2. PMID: 39836422
Supriami K, Urbut SM, …, Natarajan P, Ellinor PT, Fahed AC. Genomic Drivers of Coronary Artery Disease and Risk of Future Outcomes After Coronary Angiography. JAMA Netw Open. 2025 Jan 2. PMID: 39836422
Kim MS,…, Natarajan P, Ellinor PT, Fahed AC, Wang M. Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities. medRxiv. 2024 Nov 04. https://doi.org/10.1101/2024.11.01.24316620.
Kim MS,…, Natarajan P, Ellinor PT, Fahed AC, Wang M. Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities. medRxiv. 2024 Nov 04. https://doi.org/10.1101/2024.11.01.24316620.
Yang X, Kim MS, … Ellinor PT, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P, Wang M, Fahed AC, Wang M. An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease. medRxiv. 2024 Nov 04. https://doi.org/10.1101/2024.11.01.24316612.
Yang X, Kim MS, … Ellinor PT, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Natarajan P, Wang M, Fahed AC, Wang M. An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease. medRxiv. 2024 Nov 04. https://doi.org/10.1101/2024.11.01.24316612.
Park S, Kim S,… Fahed AC, Natarajan P, Ellinor PT, Torkamani A, Park WY, Yu TY, Myung W, Won HH. Multivariate genomic analysis of 5 million people elucidates the genetic
architecture of shared components of the metabolic syndrome. Nat Genet. 2024 Sep 30. PMID: 39349817.
Park S, Kim S,… Fahed AC, Natarajan P, Ellinor PT, Torkamani A, Park WY, Yu TY, Myung W, Won HH. Multivariate genomic analysis of 5 million people elucidates the genetic
architecture of shared components of the metabolic syndrome. Nat Genet. 2024 Sep 30. PMID: 39349817.
Nurmohamed NS… Fahed AC. Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque. JACC Cardiovasc Imaging. 2024 Aug. PMID: 39152960.
Nurmohamed NS… Fahed AC. Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque. JACC Cardiovasc Imaging. 2024 Aug. PMID: 39152960.
Kim MS… Fahed AC… Khera AV*, Won HH*. Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities. Cell Metab. 2024 Jul. PMID: 38959863.
Kim MS… Fahed AC… Khera AV*, Won HH*. Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities. Cell Metab. 2024 Jul. PMID: 38959863.
Urbut, S.M… Fahed AC… Natarajan P. MSGene: a multistate model using genetic risk and the electronic health record applied to lifetime risk of coronary artery disease. Nat Commun. 2024 Jun.
Urbut, S.M… Fahed AC… Natarajan P. MSGene: a multistate model using genetic risk and the electronic health record applied to lifetime risk of coronary artery disease. Nat Commun. 2024 Jun.
Bou Ghannam A*, Istambouli R*… Fahed AC, Hamam RN. Ocular Manifestations of Severe Familial Hypercholesterolemia. Heliyon. 2024 Apr.
Bou Ghannam A*, Istambouli R*… Fahed AC, Hamam RN. Ocular Manifestations of Severe Familial Hypercholesterolemia. Heliyon. 2024 Apr.
Mulder JWCM… Homozygous Familial Hypercholesterolemia International Clinical Collaborators. Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia. JAMA Cardiol. 2024 Apr. PMID: 38353972.
Mulder JWCM… Homozygous Familial Hypercholesterolemia International Clinical Collaborators. Sex Differences in Diagnosis, Treatment, and Cardiovascular Outcomes in Homozygous Familial Hypercholesterolemia. JAMA Cardiol. 2024 Apr. PMID: 38353972.
Abou-Karam R, Cheng F, Gady S, Fahed AC. The Role of Genetics in Advancing Cardiometabolic Drug Development. Curr Atheroscler Rep. 2024 Mar. PMID: 38451435.
Abou-Karam R, Cheng F, Gady S, Fahed AC. The Role of Genetics in Advancing Cardiometabolic Drug Development. Curr Atheroscler Rep. 2024 Mar. PMID: 38451435.
Unlu O, Fahed AC. Machine Learning in Invasive and Noninvasive Coronary Angiography. Curr Atheroscler Rep. 2023 Dec;25(12):1025-1033. PMID: 38095805
Unlu O, Fahed AC. Machine Learning in Invasive and Noninvasive Coronary Angiography. Curr Atheroscler Rep. 2023 Dec;25(12):1025-1033. PMID: 38095805
Fahed AC*, Natarajan P. Clinical applications of polygenic risk score for coronary artery disease through the life course. Atherosclerosis. 2023 Dec;386:117356. PMID: 37931336
Fahed AC*, Natarajan P. Clinical applications of polygenic risk score for coronary artery disease through the life course. Atherosclerosis. 2023 Dec;386:117356. PMID: 37931336
Bhattacharya R*, Chen N* … Gao X*, Alkuraya FS*, Fahed AC*. Massive underrepresentation of Arabs in genomic studies of common disease. Genome Med. 2023 Nov 22;15(1):99. PMID: 37993966
Bhattacharya R*, Chen N* … Gao X*, Alkuraya FS*, Fahed AC*. Massive underrepresentation of Arabs in genomic studies of common disease. Genome Med. 2023 Nov 22;15(1):99. PMID: 37993966
Urbut SM… Fahed AC…Natarajan P. MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record. medRxiv [Preprint]. 2023 Nov. PMID: 37986972
Urbut SM… Fahed AC…Natarajan P. MSGene: Derivation and validation of a multistate model for lifetime risk of coronary artery disease using genetic risk and the electronic health record. medRxiv [Preprint]. 2023 Nov. PMID: 37986972
Urbut SM… Fahed AC*, Natarajan P*. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. medRxiv [Preprint]. 2023 Nov. PMID: 37961553.
Urbut SM… Fahed AC*, Natarajan P*. Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course. medRxiv [Preprint]. 2023 Nov. PMID: 37961553.
Patel AP, Fahed AC. Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. Curr Protoc. 2023 Nov. PMID: 37921506.
Patel AP, Fahed AC. Pragmatic Approach to Applying Polygenic Risk Scores to Diverse Populations. Curr Protoc. 2023 Nov. PMID: 37921506.
Shim I*, Kuwahara H*, Chen N*,… Fahed AC. Clinical utility of polygenic scores for cardiometabolic disease in Arabs. Nat Commun. 2023 Oct. PMID: 37852978.
Shim I*, Kuwahara H*, Chen N*,… Fahed AC. Clinical utility of polygenic scores for cardiometabolic disease in Arabs. Nat Commun. 2023 Oct. PMID: 37852978.
Ayala JRT*, Fahed AC*… Philippakis A*, Doshi-Velez F*. Signature Activation: A Sparse Signal View for Holistic Saliency. arXiv preprint arXiv:2309.11443. 2023.
Ayala JRT*, Fahed AC*… Philippakis A*, Doshi-Velez F*. Signature Activation: A Sparse Signal View for Holistic Saliency. arXiv preprint arXiv:2309.11443. 2023.
Patel AP*, Wang M*… Fahed AC… Natarajan P*, Khera AV*. A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nat Med. 2023 Jul;29(7):1793-1803. PMID: 37414900P
Patel AP*, Wang M*… Fahed AC… Natarajan P*, Khera AV*. A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nat Med. 2023 Jul;29(7):1793-1803. PMID: 37414900P
Jowell A… Fahed AC… Natarajan P et al. Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease. Eur J Prev Cardiol. 2023 Apr 3:zwad096. PMID: 37011137
Jowell A… Fahed AC… Natarajan P et al. Genetic and Clinical Factors Underlying a Self-Reported Family History of Heart Disease. Eur J Prev Cardiol. 2023 Apr 3:zwad096. PMID: 37011137
Maamari DJ*, Brockman DG*… Khera AV*, Fahed AC*. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease. JACC Adv. 2022 Aug;1(3):100068. PMID: 36147540.
Maamari DJ*, Brockman DG*… Khera AV*, Fahed AC*. Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease. JACC Adv. 2022 Aug;1(3):100068. PMID: 36147540.
Fahed AC, Philippakis AA, Khera AV. The potential of polygenic scores to improve cost and efficiency of clinical trials. Nat Commun. 2022 May 25;13(1):2922. PMID: 35614072.
Fahed AC, Philippakis AA, Khera AV. The potential of polygenic scores to improve cost and efficiency of clinical trials. Nat Commun. 2022 May 25;13(1):2922. PMID: 35614072.
Fahed AC… Khera AV et al. Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease. JAMA Netw Open. 2022 Mar 1;5(3):e222687. PMID: 35294538.
Fahed AC… Khera AV et al. Association of the Interaction Between Familial Hypercholesterolemia Variants and Adherence to a Healthy Lifestyle With Risk of Coronary Artery Disease. JAMA Netw Open. 2022 Mar 1;5(3):e222687. PMID: 35294538.
Maamari DJ… Fahed AC. CYP2C19 Genotyping in Anticoagulated Patients After Percutaneous Coronary Intervention: Should It Be Routine? Circulation. 2022 Mar 8;145(10):721-723.121.057028. PMID: 35254917.
Maamari DJ… Fahed AC. CYP2C19 Genotyping in Anticoagulated Patients After Percutaneous Coronary Intervention: Should It Be Routine? Circulation. 2022 Mar 8;145(10):721-723.121.057028. PMID: 35254917.
Tromp TR… Homozygous Familial Hypercholesterolaemia International Clinical Collaborators et al. Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet. 2022 Feb 19;399(10326):719-728. PMID: 35101175.
Tromp TR… Homozygous Familial Hypercholesterolaemia International Clinical Collaborators et al. Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet. 2022 Feb 19;399(10326):719-728. PMID: 35101175.
Fahed AC, Jang IK. Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions. Nat Rev Cardiol. 2021 Oct;18(10):724-734. Epub 2021 May 5. PMID: 33953381.
Fahed AC, Jang IK. Plaque erosion and acute coronary syndromes: phenotype, molecular characteristics and future directions. Nat Rev Cardiol. 2021 Oct;18(10):724-734. Epub 2021 May 5. PMID: 33953381.
Brockman DG*, Petronio L*… Fahed AC, Khera AV. Design and user experience testing of a polygenic score report: a qualitative study of prospective users. BMC Med Genomics. 2021 Oct 1;14(1):238. PMID: 34598685.
Brockman DG*, Petronio L*… Fahed AC, Khera AV. Design and user experience testing of a polygenic score report: a qualitative study of prospective users. BMC Med Genomics. 2021 Oct 1;14(1):238. PMID: 34598685.
Fahed AC, Kathiresan S*, Khera AV* Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease. Circ Genom Precis Med..2021 Feb;14(1):e003092. Epub 2020 Dec 7. PMID: 33284643.
Fahed AC, Kathiresan S*, Khera AV* Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease. Circ Genom Precis Med..2021 Feb;14(1):e003092. Epub 2020 Dec 7. PMID: 33284643.
Fahed AC*,Nemer G*… Seidman JG*, Seidman* CE. Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2020 Oct;13(5):444-452. Epub 2020 Sep 4. PMID: 32885985.
Fahed AC*,Nemer G*… Seidman JG*, Seidman* CE. Founder Mutation in N Terminus of Cardiac Troponin I Causes Malignant Hypertrophic Cardiomyopathy. Circ Genom Precis Med. 2020 Oct;13(5):444-452. Epub 2020 Sep 4. PMID: 32885985.
Fahed AC*, Wang M*… Kathiresan S*, Khera AV*. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Nat Commun. 2020 Aug 20;11(1):3635. PMID: 32820175.
Fahed AC*, Wang M*… Kathiresan S*, Khera AV*. Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions. Nat Commun. 2020 Aug 20;11(1):3635. PMID: 32820175.
Raal FJ… ELIPSE HoFH Investigators et al. Evinacumab for Homozygous Familial Hypercholesterolemia. N Engl J Med. 2020 Aug 20;383(8):711-720. PMID: 32813947.
Raal FJ… ELIPSE HoFH Investigators et al. Evinacumab for Homozygous Familial Hypercholesterolemia. N Engl J Med. 2020 Aug 20;383(8):711-720. PMID: 32813947.
Patel AP*, Wang M*, Fahed AC… Lebo M, Khera AV. Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History. JAMA Netw Open 2020 Apr 1;3(4):e203959. PMID: 32347951.
Patel AP*, Wang M*, Fahed AC… Lebo M, Khera AV. Association of Rare Pathogenic DNA Variants for Familial Hypercholesterolemia, Hereditary Breast and Ovarian Cancer Syndrome, and Lynch Syndrome With Disease Risk in Adults According to Family History. JAMA Netw Open 2020 Apr 1;3(4):e203959. PMID: 32347951.
Fahed AC… Nemer G, Azar ST, Bitar FF. Premature Valvular Heart Disease in Homozygous Familial Hypercholesterolemia. N Cholesterol. 2017; 2017:3685265. Epub 2017 Jul 6. PMID: 28761763.
Fahed AC… Nemer G, Azar ST, Bitar FF. Premature Valvular Heart Disease in Homozygous Familial Hypercholesterolemia. N Cholesterol. 2017; 2017:3685265. Epub 2017 Jul 6. PMID: 28761763.
Saliba EC, Fahed AC. Yellow plaques on the hands of a 10-year-old girl. JAAD Online | Images in Dermatology. 2017 Jun;76(6):E193-E194.
Saliba EC, Fahed AC. Yellow plaques on the hands of a 10-year-old girl. JAAD Online | Images in Dermatology. 2017 Jun;76(6):E193-E194.
Fahed AC… Azar ST, Bitar FF, Nemer G. Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy. Mol Genet Genomic Med. 2016 Feb 24;4(3):283-91. PMID: 27247956.
Fahed AC… Azar ST, Bitar FF, Nemer G. Variable expressivity and co-occurrence of LDLR and LDLRAP1 mutations in familial hypercholesterolemia: failure of the dominant and recessive dichotomy. Mol Genet Genomic Med. 2016 Feb 24;4(3):283-91. PMID: 27247956.
Abou Hassan OK*, Fahed AC*… Seidman JG, Seidman CE, Bitar FF, Nemer GM. NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity. Sci Rep. 2015 Mar 6;5:8848. PMID: 25742962.
Abou Hassan OK*, Fahed AC*… Seidman JG, Seidman CE, Bitar FF, Nemer GM. NKX2-5 mutations in an inbred consanguineous population: genetic and phenotypic diversity. Sci Rep. 2015 Mar 6;5:8848. PMID: 25742962.
Fahed AC*… Seidman JG, Harter DH, Seidman CE. UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration. Ann Neurol. 2014 May;75(5):793-798. Epub 2014 May 9. PMID: 24771548.
Fahed AC*… Seidman JG, Harter DH, Seidman CE. UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration. Ann Neurol. 2014 May;75(5):793-798. Epub 2014 May 9. PMID: 24771548.
Fahed AC… Lakdawala NK. Heart failure in congenital heart disease: a confluence of acquired and congenital. Heart Fail Clin. 2014 Jan;10(1):219-27. PMID: 24275306.
Fahed AC… Lakdawala NK. Heart failure in congenital heart disease: a confluence of acquired and congenital. Heart Fail Clin. 2014 Jan;10(1):219-27. PMID: 24275306.
Shibbani K*, Fahed AC*… Bitar F, Majdalani M. Primary carnitine deficiency: novel mutations and insights into the cardiac phenotype. Clin Genet. 2014 Feb;85(2):127-37. Epub 2013 Mar 12. PMID: 23379544.
Shibbani K*, Fahed AC*… Bitar F, Majdalani M. Primary carnitine deficiency: novel mutations and insights into the cardiac phenotype. Clin Genet. 2014 Feb;85(2):127-37. Epub 2013 Mar 12. PMID: 23379544.
Fahed AC… Bitar FF, Haddad FF. Low-density lipoprotein levels and not mutation status predict intima-media thickness in familial hypercholesterolemia. Ann Vasc Surg. 2014 Feb;28(2):421-6. Epub 2013 Oct 9. PMID: 24120234.
Fahed AC… Bitar FF, Haddad FF. Low-density lipoprotein levels and not mutation status predict intima-media thickness in familial hypercholesterolemia. Ann Vasc Surg. 2014 Feb;28(2):421-6. Epub 2013 Oct 9. PMID: 24120234.
Fahed AC, Gelb BD, Seidman JG*, Seidman CE* Genetics of congenital heart disease: the glass half empty. Circ Res. Feb 15;112(4):707-20. Erratum in: Circ Res. 2013 Jun 7;112(12):e182. PMID: 23410880
Fahed AC, Gelb BD, Seidman JG*, Seidman CE* Genetics of congenital heart disease: the glass half empty. Circ Res. Feb 15;112(4):707-20. Erratum in: Circ Res. 2013 Jun 7;112(12):e182. PMID: 23410880
Fahed AC, Nemer G. Familial hypercholesterolemia: the lipids or the genes? Nutr Metab (Lond). 2011 Apr 22;8(1):23. PMID: 21513517.
Fahed AC, Nemer G. Familial hypercholesterolemia: the lipids or the genes? Nutr Metab (Lond). 2011 Apr 22;8(1):23. PMID: 21513517.
Fahed AC…, Azar ST, Nemer G. Homozygous familial hypercholesterolemia in Lebanon: a genotype/phenotype correlation. Mol Genet Metab. 2011 Feb;102(2):181-8. Epub 2010 Nov 11. PMID: 21145767.
Fahed AC…, Azar ST, Nemer G. Homozygous familial hypercholesterolemia in Lebanon: a genotype/phenotype correlation. Mol Genet Metab. 2011 Feb;102(2):181-8. Epub 2010 Nov 11. PMID: 21145767.
